Tridiagonal Solutions > Events > Bioprocess Understanding For Reliable Development & Transfer : The Role Of Mixing
  • Bioprocess Understanding For Reliable Development & Transfer : The Role Of Mixing

  • Save to Calendar
  • 25/03/2021 - 11:00 am - 12:00 pm CDT
  • Facebook
    Twitter
    LinkedIn
  • Fundamental process understanding plays a critical role in biopharmaceutical drug development and process transfer. Increasingly sophisticated upstream/downstream processes and the introduction of novel technologies such as single-use/disposable equipment has served to further elevate this criticality. One process consideration that is common to many key USP and DSP steps is to ensure good mixing in a vessel. This is true irrespective of the nature of the biopharmaceutical product or the process step in question – buffer/media prep, cell culture, formulation, viral clearance/inactivation etc.
     
    In this webinar, we consider this critical role that mixing plays across the spectrum of bioprocess steps in some detail. We show how a thorough understanding and characterization of mixing in bioreactors and other such vessels can ensure reliable process development, scale up and transfer. We will pay particular attention to mixing in microbial cell cultures vs animal/plant cell cultures. The importance of mixing in other process steps such as media prep, buffer prep, formulation etc. will also be treated in some detail.
     
    Mixing characterization using experimental and computational methods will also be presented. We will start by describing the appropriate set of process metrics to characterize bioprocess mixing before proceeding to a discussion on the specific methods.
     
    In keeping with the current trends in the industry, illustrative examples of engineering characterization will be provided using COTS single-use systems from major vendors (Sartorius, Millipore, Pall to name a few).
     
<< May 2021 >>
MTWTFSS
26 27 28 29 30 1 2
3 4 5 6 7 8 9
10 11 12 13 14 15 16
17 18 19 20 21 22 23
24 25 26 27 28 29 30
31 1 2 3 4 5 6
  • Register Now

    Bioprocess Understanding For Reliable Development & Transfer : The Role Of Mixing

    25/3/202111:00am CDT1 hour
    Fundamental process understanding plays a critical role in biopharmaceutical drug development and process transfer. Increasingly sophisticated upstream/downstream processes and the introduction of novel technologies such as single-use/disposable equipment has served to further elevate this criticality. One process consideration that is common to many key USP and DSP steps is to ensure good mixing in a vessel. This is true irrespective of the nature of the biopharmaceutical product or the process step in question - buffer/media prep, cell culture, formulation, viral clearance/inactivation etc.

    In this webinar, we consider this critical role that mixing plays across the spectrum of bioprocess steps. We show how a thorough understanding and characterization of mixing in bioreactors and other such vessels can ensure reliable process development, scale up and transfer. We will pay particular attention to mixing in microbial cell cultures vs animal/plant cell cultures. The importance of mixing in other process steps such as media prep, buffer prep, formulation etc. will also be treated in some detail.

    Mixing characterization using experimental and computational methods will also be presented. We will start by describing the appropriate set of process metrics to characterize bioprocess mixing before proceeding to a discussion on the specific methods.

    In keeping with the current trends in the industry, illustrative examples of engineering characterization will be provided using COTS single-use systems from major vendors (Sartorius, Millipore, Pall to name a few).

Subscribe to our Newsletter!

Pravin, one of the five members of Board of Directors in Tridiagonal Solutions has proven his expertise in creating, positioning and managing high growth companies. Mr. Jain has completed his Bachelors in Computer Engineering from University of Mumbai and Masters in Computer System Engineering from Northeastern University, Boston. He has also completed the Executive Program for Growing Companies at Stanford University Graduate School of Business. He has over 17 years of experience in Technology Entrepreneurship, Business Development and Delivery of Customer Centric Solutions. Pravin’s experience includes acquiring as well as divesting companies. Pravin lived and worked for 14 years in the US, and shifted back to India in the summer of 2006. He has driven, and been accountable for Sales, Marketing, Technology, Delivery and Strategy functions at his previous ventures. Pravin’s previous company grew by over 40x in 6 years and was subsequently divested to Wipro.

Ashish heads the software development activities at Tridiagonal Solutions. He has Post graduate degree in Fluid Mechanics and Thermal Sciences from IIT, Kanpur. Ashish is also a founder member of Tridiagonal and his interests include Computational Fluid Dynamics, Turbulence Modeling, Technical Training and Mentoring along with Open Source Software Development. Before founding Tridiagonal, Ashish worked with Fluent for seven years where he looked after product management responsibilities for Catia and FlowLab products.

Dr. Damodaran Vedapuri heads the North American Operations of Tridiagonal Solutions. He obtained his doctorate from Ohio University. Dr. Vedapuri has wide experience in Computational Fluid Dynamics, Flow Accelerated Corrosion and solving Multiphase Flow Problems of interest to the oil and gas industry. Before joining Tridiagonal, he was employed with SwRI, a premier research lab in the US and at Fluent Inc.

Dr. Damodaran Vedapuri heads the North American Operations of Tridiagonal Solutions. He obtained his doctorate from Ohio University. Dr. Vedapuri has wide experience in Computational Fluid Dynamics, Flow Accelerated Corrosion and solving Multiphase Flow Problems of interest to the oil and gas industry. Before joining Tridiagonal, he was employed with SwRI, a premier research lab in the US and at Fluent Inc.

Register Now

Register Now