Bioreactor Characterization For Reliable Process Development & Technology Transfer
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- 20/05/2021 - 11:00 am - 12:00 pm CDT
- Bioreactors are a critical upstream processing operation in the production of bio-pharmaceuticals. Operating bioreactors in a robust and reliable manner eases pressure on downstream processing steps, thus increasing overall process reliability and product quality assurance. The only meaningful path to ensure reliable bioreactor operation is via a thorough and pragmatic fundamental understanding of the reactor’s capabilities.In this webinar, we will discuss how performing an ‘engineering characterization‘ of the bioreactor enables such a pragmatic understanding. We will start by describing the appropriate set of process metrics to characterize bioreactors and then present methods (experimental and computational) to obtain them.Illustrative examples of engineering characterization will be provided using COTS bioreactors from major vendors (Sartorius, Millipore, Pall to name a few).We will further show how the information from characterization studies can be used to support process development and technology transfer activities.
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Bioreactor Characterization For Reliable Process Development & Technology Transfer
20/5/202111:00am CDT45 minutesBioreactors are a critical upstream processing operation in the production of biopharmaceuticals. Operating bioreactors in a robust and reliable manner eases pressure on downstream processing steps, thus increasing overall process reliability and product quality assurance. The only meaningful path to ensure reliable bioreactor operation is via a thorough and pragmatic fundamental understanding of the reactor's capabilities.
In this webinar, we will discuss how performing an 'engineering characterization' of the bioreactor enables such a pragmatic understanding. We will start by describing the appropriate set of process metrics to characterize bioreactors and then present methods (experimental and computational) to obtain them.
Illustrative examples of engineering characterization will be provided using COTS bioreactors from major vendors (Sartorius, Millipore, Pall to name a few).
We will further show how the information from characterization studies can be used to support process development and technology transfer activities.