Ultimately, simulations can reduce the experimental burden on the drug development process by significantly improving process insight. These insights helped to solve process challenges such as troubleshooting, scale-up and technology transfer. Standalone DEM has been used to model mixing, sieving, milling, tablet coating, hopper discharge, etc. If the fluid effects are important, like in wet granulation, drying, fluidized bed processes, wet milling, etc., then DEM-CFD two way coupling models can be used.
Check our brochure on CFD-DEM-Two-Way-Coupling