Bioreactor Scale-up/Transfer Using Fundamental Process Understanding
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- 02/02/2022 - 10:00 am - 11:00 am CST
Bioreactors are a critical upstream processing operation in the production of a wide range of biopharmaceuticals (MAbs to C&G Therapy products). Operating bioreactors in a robust and reliable manner eases pressure on downstream processing steps, thus increasing overall process reliability and product quality assurance. The only meaningful path to ensure reliable bioreactor operation is via a thorough and pragmatic fundamental understanding of the reactor’s capabilities.
In this webinar, we will discuss
a) What fundamental process understanding means in the context of bioreactor scale-up/transfer
b) Why fundamental process understanding is best represented using “process metrics”
c) How to determine estimate process metrics for various bioreactor geometries
d) How to use process metrics to perform scale-up and transfer activitiesIllustrative examples of engineering characterization will be provided using COTS single-use bioreactors from major vendors (Sartorius, Millipore, Pall to name a few).
We will further show how the information from characterization studies can be used to support process development and technology transfer activities.
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Bioreactor Scale-up/Transfer Using Fundamental Process Understanding
2/2/202210:00am CST45 minutesBioreactors are a critical upstream processing operation in the production of a wide range of biopharmaceuticals (MAbs to C&G Therapy products). Operating bioreactors in a robust and reliable manner eases pressure on downstream processing steps, thus increasing overall process reliability and product quality assurance. The only meaningful path to ensure reliable bioreactor operation is via a thorough and pragmatic fundamental understanding of the reactor's capabilities.
In this webinar, we will discuss
a) What fundamental process understanding means in the context of bioreactor scale-up/transfer
b) Why fundamental process understanding is best represented using "process metrics"
c) How to determine process metrics for various bioreactor geometries
d) How to use process metrics to perform scale-up and transfer activities
Illustrative examples of engineering characterization will be provided using COTS single-use bioreactors from major vendors (Sartorius, Millipore, Pall to name a few).
We will further show how the information from characterization studies can be used to support process development and technology transfer activities.